Spread of carbapenem-resistant Acinetobacter baumannii global clone 2 in Asia and AbaR-type resistance islands.

نویسندگان

  • Dae Hun Kim
  • Ji-Young Choi
  • Hae Won Kim
  • So Hyun Kim
  • Doo Ryeon Chung
  • Kyong Ran Peck
  • Visanu Thamlikitkul
  • Thomas Man-Kit So
  • Rohani M D Yasin
  • Po-Ren Hsueh
  • Celia C Carlos
  • Li Yang Hsu
  • Latre Buntaran
  • M K Lalitha
  • Jae-Hoon Song
  • Kwan Soo Ko
چکیده

In this surveillance study, we identified the genotypes, carbapenem resistance determinants, and structural variations of AbaR-type resistance islands among carbapenem-resistant Acinetobacter baumannii (CRAB) isolates from nine Asian locales. Clonal complex 92 (CC92), corresponding to global clone 2 (GC2), was the most prevalent in most Asian locales (83/108 isolates; 76.9%). CC108, or GC1, was a predominant clone in India. OXA-23 oxacillinase was detected in CRAB isolates from most Asian locales except Taiwan. blaOXA-24 was found in CRAB isolates from Taiwan. AbaR4-type resistance islands, which were divided into six subtypes, were identified in most CRAB isolates investigated. Five isolates from India, Malaysia, Singapore, and Hong Kong contained AbaR3-type resistance islands. Of these, three isolates harbored both AbaR3- and AbaR4-type resistance islands simultaneously. In this study, GC2 was revealed as a prevalent clone in most Asian locales, with the AbaR4-type resistance island predominant, with diverse variants. The significance of this study lies in identifying the spread of global clones of carbapenem-resistant A. baumannii in Asia.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 57 11  شماره 

صفحات  -

تاریخ انتشار 2013